Clinical Pharmacology

Thyrogen (rhTSH) decreased the mean absorbed dose to the blood by 35% thus reducing undesired radiation dose to the remainder of the body.2

  • Thyrogen results in RAI uptake comparable to thyroid hormone withdrawal (THW), with 41% greater effective half-life than THW in thyroid remnant tissue (67.6 with rhTSH vs 48 hours with THW).

Study Overview

  • 63 patients were randomized after thyroidectomy to either THW (n=30) or Thyrogen (n=33)
  • Scintigraphic neck images were acquired starting 48 hrs after RAI administration to assess biokinetics in the thyroid remnant.
  • Activity in blood samples was quantified and data from whole-body probe measurements and scintigraphic whole-body scans were combined to deduce retention curves in blood and whole body, respectively.
  • The absorbed dose to the blood was calculated.1

Thyrogen (rhTSH) increases TSH levels rapidly after administration allowing patients to remain on thyroid hormone.

Reduced numbers of patients with whole-body and blood dose data are due to technical failures during whole-body measurements.

Serum TSH Concentration1

The pharmacokinetics of rhTSH were studied in 16 patients with well differentiated thyroid cancer given a single intramuscular dose of 0.9 mg. Mean peak serum TSH concentrations of 116 ± 38 mU/L were reached between 3 and 24 hours after injection (median of 10 hours). The mean apparent elimination half-life was 25 ± 10 hours. The organ(s) of TSH clearance in humans have not been identified, but studies of pituitary-derived TSH suggest involvement of the liver and kidneys.2

The Use of Thyrogen During Remnant Ablation

Watch how patients can start on a thyroid hormone immediately after surgery, and remain euthyroid during remnant ablation with Thyrogen.

Choose how to get Thyrogen (Thyrotropin alfa) for your patients

Not sure which one to choose? Contact ThyrogenONE for assistance

Option 1: Sign up or log into the ThyrogenONE portal


The ThyrogenONE portal provides your office online access to help you and your patients :

  • Submit and track benefit verifications
  • Coordinate orders
  • Generate automatic alerts

Option 2: Call ThyrogenONE at 1-88-THYROGEN
(1-888-497-64361-888-497-6436)


Dedicated ThyrogenONE Case Managers can assist you and your patients with the following.

  • Benefits Verification
  • Information on Ordering
  • Information on specialty pharmacy fulfillment