Thyrogen (rhTSH) decreased the mean absorbed dose to the blood by 35% thus reducing undesired radiation dose to the remainder of the body.2
Thyrogen (rhTSH) increases TSH levels rapidly after administration allowing patients to remain on thyroid hormone.
Reduced numbers of patients with whole-body and blood dose data are due to technical failures during whole-body measurements.
Serum TSH Concentration1
The pharmacokinetics of rhTSH were studied in 16 patients with well differentiated thyroid cancer given a single intramuscular dose of 0.9 mg. Mean peak serum TSH concentrations of 116 ± 38 mU/L were reached between 3 and 24 hours after injection (median of 10 hours). The mean apparent elimination half-life was 25 ± 10 hours. The organ(s) of TSH clearance in humans have not been identified, but studies of pituitary-derived TSH suggest involvement of the liver and kidneys.2
The Use of Thyrogen During Remnant Ablation
Watch how patients can start on a thyroid hormone immediately after surgery, and remain euthyroid during remnant ablation with Thyrogen.
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